the Séguéla Lab

Zamfir M, Sharif B, Locke S, Ehrlich AT, Ochandarena NE, Scherrer G, Ribeiro-da-Silva A, Kieffer BL, Séguéla P. (2022) Distinct and sex-specific expression of mu opioid receptors in anterior cingulate and somatosensory S1 cortical areas. Pain Aug 15 doi: 10.1097 (Cover)

Wong C, Barkai O, Wang F, Perez CT, Lev S, Cai W, Tansley S, Yousefpour N, Hooshmandi M, Lister KC, Latif M, Cuello AC, Prager-Khoutorsky M, Mogil JS, Séguéla P, De Koninck Y, Ribeiro-da-Silva A, Binshtok AM, Khoutorsky A. (2022) mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation. Journal of Clinical Investigation 132:e152635.

Lançon K, Qu C, Navratilova E, Porreca F, Séguéla P. (2021) Decreased dopaminergic inhibition of pyramidal cells in the anterior cingulate cortex maintains chronic neuropathic pain. Cell Reports 37: 109933.

Nasseef T, Ma W, Singh JP, Dozono N, Lancon K, Séguéla P, Darcq E, Ueda H, Kieffer B.L. (2021) Chronic generalized pain disrupts whole brain functional connectivity in mice. Brain Imaging and Behavior 15:2406-2416.

Bertin E, Deluc T, Pilch KS, Martinez A, Pougnet J-T, Doudnikoff E, Allain A-E, Bergmann P, Russeau M, Toulmé E, Bezard E, Koch-Nolte F, Séguéla P, Lévi S, Bontempi B, Georges F, Bertrand SS, Nicole O, Boué-Grabot E. (2021) Increased surface P2X4 receptor expression regulates anxiety and memory in P2X4 internalization-defective knock-in mice. Molecular Psychiatry 26:629-644.

Khayachi A, Ase RA, Liao C, Kamesh A, Schorova L, Chaumette B, Dion P, Alda M, Séguéla P, Rouleau G, Milnerwood A.J. (2021) Chronic lithium treatment alters the excitatory/inhibitory balance of synaptic networks and reduces mGluR5-PKC signaling. Journal of Psychiatry and Neuroscience 46:E402-E414.

Sharif B, Ase AR, Ribeiro-da-Silva A, Séguéla P. (2020) Differential coding of itch and pain by a subpopulation of primary afferent neurons. Neuron 106:940-951.

Glasgow SD, Wong EW, Thompson-Steckel G, Marcal N, Séguéla P, Ruthazer ES, Kennedy TE. (2020) Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus. Molecular Brain 13:56.

Petitjean H, Séguéla P, Sharif-Naeini R. (2019) Bursting enables GRP neurons to engage spinal itch circuits. Neuron 103:5-7.

Ase AR, Therrien É, Séguéla P. (2019) An allosteric inhibitory site conserved in the ectodomain of P2X receptor channels. Frontiers in Cellular Neuroscience 13:121.

Waataja J, Peterson C, Verma H, Goracke-Postle C, Delpire E, Séguéla P, Wilcox G, Fairbanks C. (2019) Agmatine preferentially antagonizes GluN2B-containing N-Methyl-D-Aspartate receptors in spinal cord. Journal of Neurophysiology 121:662-671.

Cordeiro Matos S, Zamfir M, Longo G, Ribeiro da Silva A, Séguéla P. (2018) Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex. Brain Structure and Function 223:1149-64.

Bernier LP, Ase AR, Séguéla P. (2018) P2X receptor-channels in chronic pain pathways. British Journal of Pharmacology 175:2219-30.

Glasgow S, Beamish IV, Labrecque S, Wong E, Trigiani LG, Gibon J, Han D, Guido F, Hamel E, McKinney RA, De Koninck P, Séguéla P, Ruthazer E, Kennedy TE. (2018) Netrin-1 regulates glutamatergic synaptic transmission in the adult hippocampus. Cell Reports 25:168-182.

Dunn T, Fan X, Ase AR, Séguéla P, Sossin WS (2018) The CaV2α1 EF-hand F helix tyrosine, a highly conserved locus for GPCR inhibition of CaV2 channels. Scientific Reports 8:3263.

Thomas R, Gibon J, Séguéla P, Barker PA. (2018) The Nogo receptor ligand LGI1 regulates synapse number and synaptic activity in hippocampal and cortical neurons. eNeuro Sept 7;5(4).

Beaudry H, Daou I, Ase AR, Ribeiro da Silva A, Séguéla P. (2017) Distinct behavioral responses evoked by selective optogenetic stimulation of the major TRPV1+ and MrgD+ subsets of C-fibers. Pain 158:2329-39.

Beaudry H, Daou I, Ribeiro da Silva A, Séguéla P. (2017) Will optogenetics be used to treat chronic pain patients? Pain Management 7:269-78.

Uhelski ML, Bruce DJ, Séguéla P, Wilcox GL, Simone DA. (2017) In vivo optogenetic activation of Nav1.8+ cutaneous nociceptors and their responses to natural stimuli. Journal of Neurophysiology 117:2218-23.

Gibon J, Kang MS, Aliaga A, Sharif B, Rosa-Neto P, Séguéla P, Barker PA, Kostikov A. (2016) Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile. Bioorganic Medicinal Chemistry 24:4759-65.

Gibon J, Unsain N, Gamache K, Thomas RA, De Leon A, Johnstone A, Nader K, Séguéla P, Barker PA. (2016) The X-linked inhibitor of apoptosis regulates long-term depression and learning rate. FASEB Journal 30:3083-90.

Gibon J, Barker PA, Séguéla P (2016) Opposing roles of BDNF and proBDNF in the regulation of persistent activity in entorhinal cortex. Molecular Brain 9:23.

Daou I, Beaudry H, Ase AR, Wieskopf J, Ribeiro-da-Silva A, Mogil JS, Séguéla P (2016) Optogenetic silencing of Nav1.8 afferents alleviates inflammatory and neuropathic pain. eNeuro 3:0140-15.

Gaub P, Gibon J, Soubannier V, Dorval G, Séguéla P, Barker PA (2016) HbpF-proBDNF: a new tool for the analysis of pro-Brain Derived Neurotrophic Factor receptor signaling and cell biology. PLoS One 11:e0150601.

Ase AR, Honson NS, Zaghdane H, Pfeifer TA, Séguéla P. (2015) Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Molecular Pharmacology 87:606-16.

Gibon J, Buckley SM, Unsain N, Kaartinen V, Séguéla P, Barker PA. (2015) ProBDNF and p75NTR control excitability and persistent firing of cortical pyramidal neurons. Journal of Neuroscience 35: 9741-53. (co-corresponding author)

Cordeiro Matos S, Zhang Z, Séguéla P (2015) Peripheral neuropathy induces HCN channel dysfunction in pyramidal neurons of the medial prefrontal cortex. Journal of Neuroscience 35: 13244-56.

Moore CS, Ase AR, Kinsara A, Rao VTS, Michell-Robinson M, Leong SY, Butovsky O, Ludwin SK, Séguéla P, Bar-Or A, Antel JP (2015) P2Y12 expression and function in alternatively-activated human microglia. Neurology: Neuroimmunology and Neuroinflammation 2:e80.

Alkhani H, Ase AR, Grant R, O'Donnell D, Groschner K, Séguéla P. (2014) TRPC3 contributes to store-operated calcium entry and inflammatory transductions in primary nociceptors. Molecular Pain 10:43.

Mo G, Peleshok JC, Cao CQ, Ribeiro-da-Silva A, Séguéla P. (2013) Control of P2X3 channel function by metabotropic P2Y2 UTP receptors in primary sensory neurons. Molecular Pharmacology 83:640-7.

Wu C, Leong SY, Moore CS, Gris P, Bernier LP, Johnson TA, Séguéla P, Kennedy TE, Bar-Or A, Antel JP, Cui QL. (2013) Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation. Journal of Neuroinflammation 10:41. doi: 10.1186/1742-2094-10-41.

Zhang Z, Cordeiro Matos S, Jego S, Adamantidis A, Séguéla P. (2013) Norepinephrine drives persistent activity in prefrontal cortex via synergistic α1 and α2 adrenoceptors. PLoS One Jun 13;8(6):e66122.

Bernier LP, Ase AR, Boué-Grabot E, Séguéla P. (2013) Inhibition of P2X4 function by UDP-activated P2Y6 receptors in microglia. Glia 61:2038-49.

Daou I, Tuttle AH, Longo G, Ase AR, Wieskopf JS, Bonin R, De Koninck Y, Wood JN, Ribeiro-da-Silva A, Mogil JS, Séguéla P. (2013) Remote optogenetic activation and sensitization of pain pathways in freely moving mice. Journal of Neuroscience 33:18631-40.

Bernier LP, Ase AR, Séguéla P. (2013) Post-translational regulation of P2X receptor channels: modulation by phospholipids. Frontiers in Cellular Neuroscience 7:226/1-8.